Welcome

Welcome to my research group web pages. Here you can find our more information about my research group and get an overview of the kind of projects that we are currently working on. For undergraduates, you can find out how to access all of my teaching materials and resources from the 'Teaching' tab, above. There are also plenty of links to resources that we have found to be useful from all over the world, and for group members, there are many more resources, such as electronic access to theses and to our group wiki. If you require anymore information, then do not hesitate to contact me directly.



13th October

13th October

A Scalable Synthesis of the Antidepressant Agomelatine by a Tandem Allylic Chlorination–Isomerization Process

Christos I. StathakisEfstratios Neokosmidis and Theocharis V. Koftis

Eur. J. Org. Chem. 2014, 6376–6379

A concise, scalable, and industrially applicable process for the synthesis of the antidepressant agomelatine is described. The process relies on a tandem allylic chlorination–isomerization sequence, on a tetralone-derived allyl carbinol 2, as the key transformation. The target compound is obtained in five steps from commercially available 7-methoxy-1-tetralone 1, in 52.3 % overall yield after final recrystallization.

Literature october '14

Figure 1. The synthetic route to the synthesis of agomelatine purified by recrystallisation

The synthesis is among the most efficient in terms of overall yield and cost effectiveness and is well suited for large industrial production. The experimental conditions are mild and envi- ronmentally friendly. In addition, common and easily accessible chemicals are involved, while the most expensive of those, namely DDQ, was used only in catalytic amounts. Efforts for further optimization of the synthetic process are currently underway.