Dr Simon Jones, The University of Sheffield
Welcome to my group web pages. Here you can find our more information about my research group and the projects that we are currently working on. There are also plenty of links to resources that we have found to be useful from all over the world. For group members, there are many more resources, such as electronic access to theses and to our group wiki.
For undergraduates, you can access all of my teaching materials and resources from the 'Teaching' tab, above, to access support material for modules I teach.
Paper of the week - 20th January 2012
Remarkable Switch in the Regiochemistry of the Iodination of Anilines by N-Iodosuccinimide: Synthesis of 1,2-Dichloro-3,4-diiodobenzene, Hao Shen, K. Peter C. Vollhardt, Synlett, 2012, 208 - 215.Direct iodination of anilines by NIS in polar solvents (such as DMSO) affords p-iodinated products with up to >99% regioselectivity. Switching to less polar solvents (such as benzene)in the presence of AcOH inverts this outcome toward dramatically increased or preferential generation of the o-isomers, also with up to >99% regioselectivity. We found the paper interesting because of the ability of anilines to form diazonium salts which are versatile intermediates in organic synthesis. The method can therefore serve as a route to prepare key building blocks to prepare many complex molecules. Link to article |
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